How do you pronounce RYBELSUS®?

(reb-EL-sus) RYBELSUS®

What is RYBELSUS®?

RYBELSUS® is the first type 2 diabetes pill in its class (GLP-1 RA).1,2 It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.1

Can RYBELSUS® be used as a first-line treatment option for glycemic control in adult patients with T2D?

Yes, RYBELSUS®, along with diet and exercise, is a first-line option for adult patients with T2D who need A1C reduction.1

How does RYBELSUS® work?

RYBELSUS® is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that mimics the body’s native GLP-1 hormone to respond to elevated levels of blood glucose. GLP-1 RAs reduce blood glucose by stimulating insulin secretion and lowering glucagon secretion, both in a glucose-dependent manner. The mechanism of blood glucose lowering also involves a minor delay in gastric emptying in the early postprandial phase.1

The RYBELSUS® molecule is stabilized against degradation by DPP-4, prolongs incretin activity, and is coformulated with an absorption enhancer that enables once-daily oral administration.1,a

aSNAC: Sodium-N-[8-(2-hydroxybenzoyl) amino] caprylate: a small fatty-acid derivative.

Was RYBELSUS® compared to other oral antidiabetic medications in head-to-head clinical trials?

RYBELSUS® showed superior A1C reduction (as a primary endpoint) and superior weight reduction (as a confirmatory secondary endpoint) vs Januvia®.1,3 See how RYBELSUS® measured up in phase 3 clinical trials vs Januvia® and Jardiance®.

RYBELSUS® is not indicated for weight loss.

Will RYBELSUS® help my patients lose weight?

RYBELSUS® is not indicated for weight loss.

While the primary endpoint in the majority of RYBELSUS® clinical trials was mean change in A1C, mean change in body weight was generally evaluated as a confirmatory secondary endpoint. Review some of these studies for additional information and see the Prescribing Information.

What are the side effects of RYBELSUS®?

The most frequently reported adverse reactions, excluding hypoglycemia, in clinical trials that occurred in at least 5% of patients treated with RYBELSUS® were GI related, including nausea, abdominal pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and/or diarrhea occurred mostly during dose escalation. 4% and 8% of patients discontinued RYBELSUS® 7 mg and 14 mg, respectively, due to GI adverse reactions, compared to 1% of patients receiving placebo.1

How do you take RYBELSUS®?

For RYBELSUS® to work as intended, proper administration is important.1 See full dosing instructions.

How often is RYBELSUS® taken?

RYBELSUS® should be taken orally once daily, the same way every day. Patients should understand and follow all of the administration instructions for it to work as intended. Read about the proper way to take RYBELSUS®.

Does RYBELSUS® need to be refrigerated?

Unlike other GLP-1 RA therapies, RYBELSUS® should not be refrigerated. It should be stored at room temperature between 68°F–77°F (20°C–25°C) in a dry place away from moisture.1 You should discuss all the important storage information with your patients for RYBELSUS® to work as intended. See key storage information.

How long is RYBELSUS® active?

RYBELSUS® is a once-daily oral tablet. Following administration, the maximum concentration is reached after 1 hour, and the half-life is approximately 1 week. Steady-state exposure is achieved following 4 to 5 weeks of administration.

How is RYBELSUS® packaged and supplied?

RYBELSUS® tablets are available in bottles as a 30-day supply of RYBELSUS® 3 mg (green label), 7 mg (red label), or 14 mg (blue label) dosages. Read more about dosing and prescribing RYBELSUS® and find more on supplying and storage in Section 16 of the Prescribing Information.

Where can I send my patients for savings information?

Eligible patients may pay as little as $10 for a 30-, 60-, or 90-day supply of RYBELSUS®.b They can take advantage of this offer by texting READY to 21848 or by downloading a savings card at

bOffer available only to commercially insured patients with RYBELSUS® coverage. Maximum savings of $300 per 30-day supply, $600 per 60-day supply, or $900 per 90-day supply. RYBELSUS® 3 mg strength is limited to a 30-day supply only. Eligibility and restrictions apply.
cMessage and data rates may apply. Check with your mobile service provider. See Terms and Conditions of Use at

Are there other support programs available?

Signing up for savings automatically enrolls your patients in patient support. If they sign up for savings via text, they will receive text message support. If they sign up for savings online, they will receive email support. At any time, patients can call 1-833-ASK-A-CDE (1-833-275-2233) for one-on-one support from a Certified Diabetes Educator (CDE).