RYBELSUS® (semaglutide) savings and coverage tools for your patients
Novo Nordisk is here to help you get your patients started on RYBELSUS®. Use the tools below to find local coverage and patient support information.
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
Savings
Help your commercially insured patients save on RYBELSUS®
Formulary coverage
See if RYBELSUS® is covered in your area
Look up estimated cost and coverage
Find out if your patient's insurance plan covers RYBELSUS®
Savings
Help your commercially insured patients save on RYBELSUS®
Formulary coverage
See if RYBELSUS® is covered in your area
Look up estimated cost and coverage
Find out if your patient's insurance plan covers RYBELSUS®
We’re committed to patient savings and support
Patients can get the savings offer in 2 ways:
When signing up for savings, patients can also enroll in patient support
If patients sign up for savings via text, they can also receive text message support.
If patients sign up for savings online, they can also receive email support.
aOffer available only to commercially insured patients with RYBELSUS® coverage. Maximum savings of $300 per 30-day supply, $600 per 60-day supply, or $900 per 90-day supply. RYBELSUS® 3 mg strength is limited to a 30-day supply only. Eligibility and restrictions apply.
bMessage and data rates may apply. Check with mobile service provider. See Terms and Conditions of Use at RYBELSUS.com.
Pharmacists: Have questions about processing the RYBELSUS® savings offer?
Call the Change Healthcare Pharmacy Help desk at 1-800-433-4893 to get answers.
Available Monday to Friday, 8:00 am – 8:00 pm ET, except holidays.
Medicare Part D: Are your patients aged 65+ with T2D looking for improved A1C control?
See how RYBELSUS® compares with some other oral antidiabetic therapies
*Novo Nordisk defines access as covered when brand is available on formulary with or without restrictions. Coverage status and tier vary by plan and are subject to change. Please check directly with health plan to confirm coverage for individual patients.
T2D=Type 2 diabetes.
Actor portrayal of hypothetical patient
Growing formulary coverage for RYBELSUS®
Find out which plans in your area include RYBELSUS®. Formulary status is believed to be accurate at the time of update but cannot be guaranteed.
RYBELSUS® has
∼99%
commercial coverage
vs 88.6% for Januvia®c
RYBELSUS® is covered by the top 5 plans.d,e
cCalculated with noninsulin antidiabetic drugs (NIAD) market volume (previously GLP-1) to prepare for RYBELSUS® access calculations. Sources: Data from MMIT Formulary bridge. October 2022 Nomenclature, and Xponent PlanTrak using week-ending 11/11/2022; only considers bridged volume; excludes cash and mail order data; based on full DCS/EDCS/CARD/OCS IC universe (Targets + Non-Targets). Unrestricted defined as Preferred + Covered.
dNovo Nordisk defines formulary coverage as Preferred, Covered, or Covered with Restrictions. Coverage status and tier vary by plan and are subject to change. Please check directly with the health plan to confirm coverage for individual patients.
ePlan data based on number of pharmacy lives as reported by Managed Markets Insight & Technology, LLC (current as of October 2022). Applies to commercial business only. Formulary status is subject to change. Because formularies do change, and many health plans offer more than one formulary, please check directly with the health plan to confirm coverage for individual patients. 2022 Managed Markets Insight & Technology, LLC.
Our resource for patient affordability and access support for RYBELSUS®
NovoCare® offers a cost navigator tool, savings cards, support, and more.
Estimate patient costs in minutes
Find a patient’s coverage status and estimated prescription cost in minutes. Your patient’s pharmacy prescription card information may be needed and you may need to start a prior authorization.
Important Safety Information for RYBELSUS® (semaglutide) tablets 7 mg or 14 mg
WARNING: RISK OF THYROID C-CELL TUMORS
- In rodents, semaglutide causes dose-dependent and treatment-duration dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether RYBELSUS® causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined
- RYBELSUS® is contraindicated in patients with a personal or family history of MTC and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of RYBELSUS® and inform them of symptoms of thyroid tumors (e.g. a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with RYBELSUS®
Indication and Usage
RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
Limitations of Use
- RYBELSUS® has not been studied in patients with a history of pancreatitis. Consider other antidiabetic therapies in patients with a history of pancreatitis
- RYBELSUS® is not indicated for use in patients with type 1 diabetes
Important Safety Information
Contraindications
- RYBELSUS® is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), and in patients with a prior serious hypersensitivity reaction to semaglutide or to any of the excipients in RYBELSUS®. Serious hypersensitivity reactions including anaphylaxis and angioedema have been reported with RYBELSUS®
Warnings and Precautions
- Risk of Thyroid C-Cell Tumors: Patients should be further evaluated if serum calcitonin is measured and found to be elevated or thyroid nodules are noted on physical examination or neck imaging
- Pancreatitis: Has been reported in clinical trials. Observe patients carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting). If pancreatitis is suspected, discontinue RYBELSUS® and initiate appropriate management; if confirmed, do not restart RYBELSUS®
- Diabetic Retinopathy Complications: In a pooled analysis of glycemic control trials with RYBELSUS®, patients reported diabetic retinopathy related adverse reactions during the trial (4.2% with RYBELSUS® and 3.8% with comparator). In a 2-year trial with semaglutide injection involving patients with type 2 diabetes and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide injection (3.0%) compared to placebo (1.8%). The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline than among patients without a known history of diabetic retinopathy.
Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy. Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy - Hypoglycemia: Patients receiving RYBELSUS® in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia. Inform patients using these concomitant medications of the risk of hypoglycemia and educate them on the signs and symptoms of hypoglycemia
- Acute Kidney Injury: There have been postmarketing reports of acute kidney injury and worsening of chronic renal failure, which may sometimes require hemodialysis, in patients treated with GLP-1 receptor agonists, including semaglutide. Some of these events have been reported in patients without known underlying renal disease. A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration. Monitor renal function when initiating or escalating doses of RYBELSUS® in patients reporting severe adverse gastrointestinal reactions
- Hypersensitivity: Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) have been reported in patients treated with RYBELSUS®. If hypersensitivity reactions occur, discontinue use of RYBELSUS®, treat promptly per standard of care, and monitor until signs and symptoms resolve. Use caution in a patient with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist
- Acute Gallbladder Disease: Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing. In placebo-controlled trials, cholelithiasis was reported in 1% of patients treated with RYBELSUS® 7 mg. Cholelithiasis was not reported in RYBELSUS® 14 mg or placebo-treated patients. If cholelithiasis is suspected, gallbladder studies and appropriate clinical follow-up are indicated
Adverse Reactions
- Most common adverse reactions (incidence ≥5%) are nausea, abdominal pain, diarrhea, decreased appetite, vomiting and constipation
Drug Interactions
- RYBELSUS® stimulates insulin release in the presence of elevated blood glucose concentrations. When initiating RYBELSUS®, consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia
- RYBELSUS® delays gastric emptying and has the potential to impact the absorption of other oral medications. Closely follow RYBELSUS® administration instructions when coadministering with other oral medications and consider increased monitoring for medications with a narrow therapeutic index, such as levothyroxine
Use in Specific Populations
- Pregnancy: Available data with RYBELSUS® are not sufficient to determine a drug-associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Based on animal reproduction studies, there may be risks to the fetus from exposure to RYBELSUS®. Use only if the potential benefit justifies the potential risk to the fetus
- Lactation: There are no data on the presence of semaglutide in human milk, the effects on the breastfed infant, or the effects on milk production. Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of salcaprozate sodium (SNAC), an absorption enhancer in RYBELSUS®, from breastfeeding and because there are alternative formulations of semaglutide that can be used during lactation, advise patients that breastfeeding is not recommended during treatment with RYBELSUS®
- Discontinue RYBELSUS® in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide
- Pediatric Use: Safety and effectiveness of RYBELSUS® have not been established in pediatric patients
Please click here for Prescribing Information, including Boxed Warning.
References:
- Data from MMIT Formulary bridge through January 2023 Nomenclature, and Xponent PlanTrak using week-ending 1/20/2023; only considers bridged volume; excludes cash and mail order data.
- IQVIA LAAD December 2022.