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Dr Ralph DeFronzo discusses 8 core defects implicated in the pathogenesis of type 2 diabetes as described during his "Ominous Octet" Banting lecture presented in 2008. He also reviews the role of glucagon-like-peptide-1 (GLP-1) in many of the core defects present in type 2 diabetes.
In this video, Dr Leahy describes the incretin effect and the role of native glucagon-like peptide-1 (GLP-1) in digestion and blood glucose regulation in normal physiology.
In this video, Dr David D’Alessio discusses the importance of islet dysfunction in type 2 diabetes, reviews the incretin effect, and describes the role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes.