See efficacy and safety profile data for patients with:
Congenital Hemophilia A or B With Inhibitors
Acquired Hemophilia
Congenital Factor VII Deficiency
Glanzmann’s Thrombasthenia
Dosing tools and recommendations
Use this convenient dosing calculator
With this dosing calculator, you can quickly determine the recommended NovoSeven® RT dose for your patient, plus the number of vials required.*
*As a reminder, for US health care professionals only.
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recommendations
The quick reference dosing page provides recommended doses for all indications.
Steps for administering NovoSeven® RT
MixPro® makes preparing a dose of NovoSeven® RT fast for your patients.
The #1 prescribed rFVIIa in hospitals.5
NovoSeven® RT is approved for bleed control and perioperative management in a wide range of indications.1 NovoSeven® RT is the only rFVIIa that has clinical study experience with Hemlibra® for patients with CHAwI.6 Explore information and clinical pathways for treating bleeding episodes and for perioperative management.
The #1 prescribed rFVIIa in hospitals.5
NovoSeven® RT is approved for bleed control and perioperative management in a wide range of indications.1 NovoSeven® RT is the only rFVIIa that has clinical study experience with Hemlibra® for patients with CHAwI.6 Explore information and clinical pathways for treating bleeding episodes and for perioperative management.
Other tools and resources to help you and your patients
How NovoSeven® RT works
Review the mechanism of action (MOA) of NovoSeven® RT for congenital hemophilia with inhibitors.
Ordering NovoSeven® RT
Learn how you can order NovoSeven® RT for your patients with rare bleeding disorders.
Education for you
Browse educational materials for health care professionals who treat patients with bleeding disorders.
Support for patients
See how we may be able to help your patients with insurance coverage or financial assistance.
Education for you
Browse educational materials for health care professionals who treat patients with bleeding disorders.
Support for patients
See how we may be able to help your patients with insurance coverage or financial assistance.
Questions about how NovoSeven® RT can help your patients?
Selected Important Safety Information for NovoSeven® RT
WARNING: THROMBOSIS
- Serious arterial and venous thrombotic events following administration of NovoSeven® RT have been reported
- Discuss the risks and explain the signs and symptoms of thrombotic and thromboembolic events to patients who will receive NovoSeven® RT
- Monitor patients for signs or symptoms of activation of the coagulation system and for thrombosis
Warnings and Precautions
- Serious arterial and venous thrombotic events have been reported in clinical trials and postmarketing surveillance
- Patients with congenital hemophilia receiving concomitant treatment with aPCCs (activated prothrombin complex concentrates), older patients particularly with acquired hemophilia and receiving other hemostatic agents, and patients with a history of cardiac and vascular disease may have an increased risk of developing thrombotic events
Indications and Usage
NovoSeven® RT (coagulation Factor VIIa, recombinant) is a coagulation factor indicated for:
- Treatment of bleeding episodes and perioperative management in adults and children with hemophilia A or B with inhibitors, congenital Factor VII (FVII) deficiency, and Glanzmann’s thrombasthenia with refractoriness to platelet transfusions, with or without antibodies to platelets
- Treatment of bleeding episodes and perioperative management in adults with acquired hemophilia
Important Safety Information
WARNING: THROMBOSIS
- Serious arterial and venous thrombotic events following administration of NovoSeven® RT have been reported
- Discuss the risks and explain the signs and symptoms of thrombotic and thromboembolic events to patients who will receive NovoSeven® RT
- Monitor patients for signs or symptoms of activation of the coagulation system and for thrombosis
Warnings and Precautions
- Serious arterial and venous thrombotic events have been reported in clinical trials and postmarketing surveillance
- Patients with congenital hemophilia receiving concomitant treatment with aPCCs (activated prothrombin complex concentrates), older patients particularly with acquired hemophilia and receiving other hemostatic agents, and patients with a history of cardiac and vascular disease may have an increased risk of developing thrombotic events
- Hypersensitivity reactions, including anaphylaxis, can occur with NovoSeven® RT. Patients with a known hypersensitivity to mouse, hamster, or bovine proteins may be at a higher risk of hypersensitivity reactions. Discontinue infusion and administer appropriate treatment when hypersensitivity reactions occur
- Factor VII deficient patients should be monitored for prothrombin time (PT) and factor VII coagulant activity (FVII:C). If FVII:C fails to reach the expected level, or PT is not corrected, or bleeding is not controlled after treatment with the recommended doses, antibody formation may be suspected and analysis for antibodies should be performed
- Laboratory coagulation parameters (PT/INR, aPTT, FVII:C) have shown no direct correlation to achieving hemostasis
Adverse Reactions
- The most common and serious adverse reactions in clinical trials are thrombotic events. Thrombotic adverse reactions following the administration of NovoSeven® RT in clinical trials occurred in 4% of patients with acquired hemophilia and 0.2% of bleeding episodes in patients with congenital hemophilia
Drug Interactions
- Thrombosis may occur if NovoSeven® RT is administered concomitantly with Coagulation Factor XIII
Please click here for NovoSeven® RT Prescribing Information, including Boxed Warning.
- Data on file. Novo Nordisk Inc; Plainsboro, NJ.
- NovoSeven RT [package insert]. Plainsboro, NJ: Novo Nordisk Inc; 2020.
- FEIBA [package insert]. Westlake Village, CA: Baxter Healthcare Corporation; 2020.
- Obizur [package insert]. Westlake Village, CA: Baxter Healthcare Corporation; 2021.
- Data on file as of 2021. Novo Nordisk Inc; Plainsboro, NJ.
- Levy GG, Asikanius E, Kuebler P, et al. Safety analysis of rFVIIa with emicizumab dosing in congenital hemophilia A with inhibitors: experience from the HAVEN clinical program. J Thromb Haemost. 2019;17(9):1470-1477.