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Zegalogue® (dasiglucagon) injection 0.6mg/0.6mL logo
Important Safety Information | Patient Site
Prescribing Information
    • Identifying the risk
    • The importance of rescue treatment
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Zegalogue® (dasiglucagon) injection 0.6mg/0.6mL logo

Prescribing Information
Important Safety Information | Patient Site

Hypoglycemia is common in diabetes1

Patients taking insulin can experience an average of ≥1 severe hypoglycemic events per year1,2

percentage of people with T2D experience SHE

CLASSIFICATION OF HYPOGLYCEMIA3

Classification of Severe Hypoglycemia chart
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The patients you see every day may face a risk for severe hypoglycemia4

The American Diabetes Association recommends that glucagon be prescribed for all individuals at increased risk of level 2 or 3 hypoglycemia so that it is available should they have a severe hypoglycemic event3

IMPORTANCE OF RESCUE TREATMENT

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Indication and Usage for ZEGALOGUE® (dasiglucagon) injection 0.6 mg/0.6 mL

ZEGALOGUE® (dasiglucagon) injection is indicated for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes aged 6 years and above.

Important Safety Information

Contraindications

ZEGALOGUE® is contraindicated in patients with pheochromocytoma because of the risk of substantial increase in blood pressure and in patients with insulinoma because of the risk of hypoglycemia.

Warnings and Precautions

  • ZEGALOGUE® is contraindicated in patients with pheochromocytoma because glucagon products may stimulate the release of catecholamines from the tumor. If the patient develops a substantial increase in blood pressure and a previously undiagnosed pheochromocytoma is suspected, 5 to 10 mg of phentolamine mesylate, administered intravenously, has been shown to be effective in lowering blood pressure.
  • In patients with insulinoma, administration of glucagon products may produce an initial increase in blood glucose; however, ZEGALOGUE® administration may directly or indirectly (through an initial rise in blood glucose) stimulate exaggerated insulin release from an insulinoma and cause hypoglycemia. ZEGALOGUE® is contraindicated in patients with insulinoma. If a patient develops symptoms of hypoglycemia after a dose of ZEGALOGUE®, give glucose orally or intravenously.
  • Allergic reactions have been reported with glucagon products; these include generalized rash, and in some cases anaphylactic shock with breathing difficulties and hypotension. Advise patients to seek immediate medical attention if they experience any symptoms of serious hypersensitivity reactions.
  • ZEGALOGUE® is effective in treating hypoglycemia only if sufficient hepatic glycogen is present. Patients in states of starvation, with adrenal insufficiency or chronic hypoglycemia may not have adequate levels of hepatic glycogen for ZEGALOGUE® administration to be effective. Patients with these conditions should be treated with glucose.

Adverse Reactions 

  • The most common adverse reactions (≥2%) associated with ZEGALOGUE® in adults were nausea, vomiting, headache, diarrhea and injection site pain; in pediatrics: nausea, vomiting, headache and injection site pain.

Drug Interactions

  • Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given ZEGALOGUE®. In patients taking indomethacin, ZEGALOGUE® may lose its ability to raise blood glucose or may produce hypoglycemia. ZEGALOGUE® may increase the anticoagulant effect of warfarin.

Please see Zegalogue® Full Prescribing Information.

References: 1. International Hypoglycaemia Study Group. Minimizing hypoglycemia in diabetes. Diabetes Care. 2015;38(8):1583-1591. doi:10.2337/dc15-0279 2. Edridge CL, Dunkley AJ, Bodicoat DH, et al. Prevalence and incidence of hypoglycaemia in 532,542 people with type 2 diabetes on oral therapies and insulin: a systematic review and meta-analysis of population based studies. PLoS One. 2015;10(6):e0126427. doi:10.1371/journal.pone.0126427 3. American Diabetes Association. 6. Glycemic targets: Standards of Medical Care in Diabetes—2021. Diabetes Care. 2021;44(suppl 1):S73-S84. doi:10.2337/dc21-S006 4. American Diabetes Association. 6. Glycemic targets: Standards of Medical Care in Diabetes—2020. Diabetes Care. 2020;43(suppl 1):S66-S76. doi:10.2337/dc20-S006

Diabetes
Other Therapy Areas
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Explore obesity
Explore rare bleeding disorders
Explore growth-related disorders
Explore hormone replacement therapy
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Zegalogue®, Cornerstones4Care®, NovoCare®, NovoFine Plus®, NovoFine®, and NovoTwist® are registered trademarks and novoMEDLINK™ is a trademark of Novo Nordisk A/S.

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