Rare Bleeding Disorders
Other Therapy Areas
Explore diabetes
Explore obesity
Explore growth-related disorders
Explore rare bleeding disorders
Explore rare renal disorders
Explore hormone replacement therapy
Medical Information | Non-US Health Care Professionals
Account Settings
Sign Out
Sign In | Create Account
  • Rare Bleeding Disorders Home
    • Products
      Our Treatments How to Order Trial Prescriptions Recombinant Manufacturing
    • Professional Resources
      Product Resources Library Contact Your Representative
    • Disease Education
      Clinical Education Library Congenital Hemophilia with Inhibitors Breakthrough Bleeds Acquired Hemophilia Glanzmann's Thrombasthenia Interactive Joint Bleed Model
    • Treatment Guidelines
      MASAC Guidelines WFH Guidelines
    • Additional Resources
      Organizations & Conferences
    • Product Education
      Product Education Materials
    • Disease Education
      Disease Education Resources
    • Access & Affordability
      Prescription Savings & Insurance Support ICD-10 Codes for Rare Bleeding Disorders
  • Sign In
    Create Account
    • Account Settings
    • Sign Out
    Other Therapy Areas
    Medical Information
    Non-US Health Care Professionals
Glanzmann's Thrombasthenia
Glanzmann's Thrombasthenia
  • Overview
  • Diagnosing
  • Diagnostic Algorithm

Diagnosing Glanzmann’s thrombasthenia

Because Glanzmann’s thrombasthenia (GT) shares symptoms with other acquired platelet disorders and von Willebrand disease, diagnosis is often missed.1,2

Diagnosing Glanzmann’s thrombasthenia

Because Glanzmann’s thrombasthenia (GT) shares symptoms with other acquired platelet disorders and von Willebrand disease, diagnosis is often missed.1,2

Common signs and symptoms of GT4,a

Most patients with GT begin experiencing symptoms—such as epistaxis and easy bruising—in childhood. Common signs of GT also include heavy menstrual bleeding and gingival bleeding.2,4

Common signs and symptoms of GT
Common signs and symptoms of GT

Importance of a correct diagnosis

Diagnosing Glanzmann’s thrombasthenia can be difficult because it requires careful analysis of medical history, family history and clinical presentation. ~26% of patients with GT can experience severe bleeding episodes; a correct diagnosis is vital for patient health.1,3,a

aBased on data from Glanzmann’s Thrombasthenia Registry (GTR).

How do patients with GT present?

The following actual patient cases provide insight into typical GT symptoms. Recognizing these symptoms may be the first step toward an accurate GT diagnosis.

Actor portrayal

Epistaxis
2.5-year-old female5

2.5 year-old patient presented to emergency department with >1-hour episode of severe epistaxis and history of recurrent epistaxis (~2-3 bleeding episodes per month and easy bruising).

Actor portrayal

Heavy menstrual bleeding
14-year-old female6

14 year-old patient presented with heavy menstrual bleeding requiring 10 tampons per day. The patient had a history of gingival bleeding and epistaxis and was diagnosed with GT at 8 years old.

  

Gingival bleeding
18-year-old male7

18 year-old patient presented with an average hemoglobin of 3.6 g/dL over the past 6 months from chronic gingival bleeding alone. The patient was diagnosed at 2 years old and has a history of chronic gingivitis and associated gum bleeds since early childhood.

ED=emergency department.
These are actual patient cases.

A diagnostic algorithm for Glanzmann’s thrombasthenia

Learn about the steps to diagnosing Glanzmann’s thrombasthenia in the emergency department.

Go to diagnostic algorithm

References:

  1. Solh T, Botsford A, Solh M. Glanzmann’s thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. J Blood Med. 2015;6:219-227.
  2. Lambert MP. What to do when you suspect an inherited platelet disorder. Hematology Am Soc Hematol Educ Program. 2011;2011:377-383.
  3. Di Minno G, Zotz RB, d’Oiron R, et al. The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of non-surgical bleeding episodes in patients with Glanzmann thrombasthenia. Haematologica. 2015;100(8):1031-1037.
  4. Poon MC, Di Minno G, d’Oiron R, et al. New insights into the treatment of Glanzmann thrombasthenia. Transfus Med Rev. 2016;30(2):92-99
  5. Recht M et al. Epistaxis as a common presenting symptom of Glanzmann’s thrombasthenia, a rare qualitative platelet disorder: illustrative case examples. Case Rep Emerg Med. 2017:8796425.
  6. Lu M, Yang X. Levonorgestrel-releasing intrauterine system for treatment of heavy menstrual bleeding in adolescents with Glanzmann's Thrombasthenia: illustrated case series. BMC Womens Health. 2018;18(1):45.
  7. Ghosh A et al. Total extraction as a treatment for anaemia in a patient of Glanzmann’s Thrombasthenia with chronic gingival bleed: case report. J Clin Diagn Res. 2016;10(1):ZD11-ZD12.
Rare Bleeding Disorders
Other Therapy Areas
Explore diabetes
Explore obesity
Explore growth-related disorders
Explore rare bleeding disorders
Explore rare renal disorders
Explore hormone replacement therapy
  • Rare Bleeding Disorders Home
  • Product Information
    Products
    • Our Treatments
      How to Order
      Trial Prescriptions
      Recombinant Manufacturing
    Professional Resources
    • Product Resources Library
      Contact Your Representative
  • Professional Education
    Disease Education
    • Clinical Education Library
      Congenital Hemophilia with Inhibitors
      Breakthrough Bleeds
      Acquired Hemophilia
      Glanzmann's Thrombasthenia
      Interactive Joint Bleed Model
    Treatment Guidelines
    • MASAC Guidelines
      WFH Guidelines
    Additional Resources
    • Organizations & Conferences
  • Patient Support
    Product Education
    • Product Education Materials
    Disease Education
    • Disease Education Resources
    Access & Affordability
    • Prescription Savings & Insurance Support
      ICD-10 Codes for Rare Bleeding Disorders

novoMEDLINK™ is a trademark of Novo Nordisk A/S.
Novo Nordisk is a registered trademark of Novo Nordisk A/S.
Non-US Health Care Professionals, please go to pro.novonordisk.com.

Terms of Use | Privacy Notice | Consumer Health Privacy Notice | Cookie Notice | Privacy Request | Contact Us |
novonordisk-us.com    
© 2023 Novo Nordisk All rights reserved. US23HCP00056 August 2023

Quick links

Trial prescription programs

Patient access and affordability options

MASAC treatment guidelines

Patient educational materials