Glucagon: A Major Player in Type 2 Diabetes (6:42)

In this video, Dr Charles Reasner provides insight into the important role of glucagon in glucose homeostasis and type 2 diabetes. 

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Glucagon: A Major Player in Type 2 Diabetes (6:42)

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Transcript
References

In this video, Dr Charles Reasner provides insight into the important role of glucagon in glucose homeostasis and type 2 diabetes.

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References

1. DeFronzo RA. Banting Lecture. From the triumvirate to the
    ominous octet: a new paradigm for the treatment of type
    2 diabetes mellitus. Diabetes. 2009;58(4):773-795.

2. Gerich JE. Role of the kidney in normal glucose
    homeostasis and in the hyperglycaemia of diabetes
    mellitus: therapeutic implications. Diabet Med. 2010;
    27(2):136-142.

3. Baron AD, Schaeffer L, Shragg P, Kolterman OG. Role
    of hyperglucagonemia in maintenance of increased
    rates of hepatic glucose output in type II diabetics. 
    Diabetes. 1987;36(3):274-283.

4. Henquin JC, Rahier J. Pancreatic alpha cell mass in
    European subjects with type 2 diabetes. Diabetologia.
    2011;54(7):1720-1725.

5. Drucker DJ. Glucagon-like peptides: regulators of cell
    proliferation, differentiation, and apoptosis. Mol 
    Endocrinol. 2003;17(2):161-171.

6. Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B,
    Creutzfeld W. Normalization of fasting hyperglycaemia
    by exogenous glucagon-like peptide 1 (7-36 amide) in
    Type 2 (non-insulin-dependent) diabetic patients. 
    Diabetologia. 1993;36(8):741-744.

7. Bagger JI, Knop FK, Lund A, Holst JJ, Vilsbøll T.
    Glucagon responses to increasing oral loads of glucose
    and corresponding isoglycaemic intravenous glucose
    infusions in patients with type 2 diabetes and healthy
    individuals. Diabetologia. 2014;57(8):1720-1725.

8. Müller WA, Faloona GR, Aguilar-Parada E, Unger
    GH. Abnormal alpha-cell function in diabetes.
    Response to carbohydrate and protein ingestion. 
    N Engl J Med. 1970;283(3):109-115.