NOVOMEDLINK™

FPG and PPG Coverage

NovoLog® Mix 70/30 was designed to mimic normal insulin secretion when taken at mealtime

The following chart demonstrates a normal insulin profile — one that peaks at mealtime and gradually lowers. NovoLog® Mix 70/30 was designed to resemble this secretion pattern.

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Adapted 2007 with permission, Polonsky et al, 1988.16

NovoLog® Mix 70/30 is one insulin with both fasting (FPG) and mealtime (PPG) control16,41

  • Contains no NPH insulin
  • 70% is engineered for extended action (up to 24 hours)
  • 30% is available immediately

One injection at each meal corresponds with a normal insulin
secretion pattern

Adapted from Weyer et al, 1997.39

NovoLog® Mix 70/30 can be dosed one, two, or three times per day, depending on your patients' needs.40

NovoLog® Mix 70/30 is typically dosed twice daily.

NovoLog® Mix 70/30 is indicated for the treatment of patients with diabetes mellitus for the control of hyperglycemia.

NovoLog® Mix 70/30 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® Mix 70/30 or one of its excipients.



  1. NovoLog® Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, [rDNA origin]) Indications and Usage

    NovoLog® Mix 70/30 is indicated for the treatment of patients with diabetes mellitus for the control of hyperglycemia.

    NovoLog® Mix 70/30 Important Safety Information

    NovoLog® Mix 70/30 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® Mix 70/30 or one of its excipients.

    Because NovoLog® Mix 70/30 has peak pharmacodynamic activity 1 hour after injection, it should be administered with meals. Hypoglycemia is the most common adverse effect of insulin therapy, including NovoLog® Mix 70/30. As with all insulins, the timing of hypoglycemia may differ among various insulin formulations. Glucose monitoring is recommended for all patients with diabetes. Any change of insulin should be made cautiously and only under medical supervision. Changes in insulin strength, manufacturer, type, species, or method of manufacture may result in the need for a change in dosage. Potential side effects associated with the use of all insulins include hypoglycemia, hypokalemia, lipodystrophy, and allergic reactions.

    Because of differences in the action of NovoLog® Mix 70/30 and other insulins, care should be taken in patients in whom these conditions may be clinically relevant (eg, patients who are fasting, have autonomic neuropathy, are using potassium-lowering drugs, or are taking drugs sensitive to serum potassium level). Do not mix NovoLog® Mix 70/30 with any other insulin product.

    As with other insulin therapy, erythema, swelling, and pruritus at the injection site have been observed with NovoLog® Mix 70/30. Less common but more serious are severe cases of generalized allergy, including anaphylactic reaction, which may be life threatening. NovoLog® Mix 70/30 dose requirements may be reduced in the presence of renal impairment or impaired hepatic function. Changes in cross-reactive antibodies were more common after NovoLog® Mix 70/30 than with human premixed 70/30, but the clinical significance of these antibodies has not been established. Frequency of adverse events comparable with that of human 70/30. Local injection site reactions comparable with those of human 70/30.

    Please see Prescribing Information.